This page is not the permanent home of the following information. This will transition knowledge into the new format of the wiki.

Running into a wall/step within close hearing range, while disguised and partially/fully out of sight (e.g. Research Lab I.) exposes you
The amount of time lost by using a Wait is a little less than 2 seconds.
Loading and exiting a Stage to pass time for Reports loses around 9s IGT each time. The worst amount of “Extra Exfils” needed on NG runs with the right spy setup resides at 4 times. =36s IGT timeloss due to RNG
For NG runs, the worst amount of total possible time lost to Report/Development RNG lies just below 1m 30s
The game is supposed to prevent you from planting TNT anywhere during the Python boss fight. However, you can plant TNT on the “cage walls” when leaning against it and on top of its path
The difficulty of Boss Rush is always fixed to Normal
Having Sokolov (Ghost) anywhere among your staff will remove the Ghost entry from your Codec's contact list. Dismissing him immediately reverts this change.

m37 on rail bridge 2 & 3 smoke g on guest house

All currently documented Box Travel Strats can be found in this playlist: https://youtube.com/playlist?list=PLfJ5hi4JjGcRaBLpA_N1JLCMvB0b-CAYb
So far, these are mostly to be used on the NG Any% Route.

So far, since we can only estimate when exactly the IGT stops counting (do transitions count or does IGT stop right after you hit Start?), I went with the most conservative timing approach - timing with the highest possible IGT.
Same goes for every Member Swap into instant Pause to Member Swap again, where I've added 0.8s each time.
I took a similar approach while finding strats. Only using Member Swaps that are 100% guaranteed to be faster - while assuming that Pause Transitions are counted in the IGT.

Based on the above principles, I went with the following rule of thumb to find 100% guaranteed faster Box Swap strats:
NG: If the Box you're swapping to touches the Daytime Sense Ring of your active soldier with 40 SNS from the inside, it will be faster than just running.
NG+: If the Box you're swapping to touches the Daytime Sense Ring of your active soldier with 50 SNS from the inside, it will be faster than just running.

HPT		6s save
RL1 		4s save
Menu Jo #2	3s loss
SD2 		8s save
RB1 		3s save
Spy Reports 	3s loss min, 6s loss avg
----------
SD3		2s save
RL2		2s save
SPB2		4s save
----------
RB2		2s save
HB		1s save
(Menu Jo) 	0-3s loss 
SB 		2s save
WS		8s save
Menu Re in	1s loss
(Menu Jo) 	0-3s loss 
A		5s save
SE1		1s save
SE2		1s save
RB3		<1s save
GH		15s save
Sn#1, Jo#2	<1s loss
P		3s save
Menu Py in	2s loss
R		5s save
PS1		/
(Menu Py) 	0-6s loss 
PS2		/
SE3		<1s save
SC		3s save

https://cdn.discordapp.com/attachments/360699775215206401/994293524029788200/MPO_-_Lethality_of_Incoming_Damage_across_different_Versions.png

Make NG+/EXTREME version of this ^