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Advanced Mode Nikita Level 5
Image provided from the Metal Gear Ghost Babel Official Guide
Your First Step is to cause an ALERT so the Guard comes down to the Entry point instead of you guiding your Nikita missile through the level. You want to cause at least two alerts with a short caution in between. This is because the time duration isn't long enough for the Guard to find you. At least two short alerts caused my two missiles shot at the nearby wall. You can also keep shooting your Nikita until he arrives, but the more missiles you conserve, the better your time.
When the guard eventually spots you in your spawn point, you want him to shoot you half a second before you shoot him. The damage frames from the guards shot will protect you from the Nikita blast of when the guard takes a direct hit from your missile. All this is done because it's shorter to do this than to navigate through the level.